plays a central role in DNA repair by cleaving the DNA backbone 5′ of AP sites that result from removal of damaged bases. New structural findings on APE1–DNA cocrystals provide insights into ...

In DNA, 2-deoxy-D-ribose molecules link together through phosphate groups to form a sugar-phosphate backbone. This backbone ...

The sugar-phosphate backbone forms the structural framework of nucleic acids, including DNA and RNA. This backbone is composed of alternating sugar and phosphate groups, and defines directionality ...

The famous DNA double helix is considered right-handed, meaning its spiral strands — a sugar-phosphate backbone — twist to the right. (To picture this, make a thumbs-up with your right hand ...