脂质筏（LRs）作为细胞膜的重要组织者，在细胞信号传导中发挥关键作用。其富含胆固醇、鞘脂等成分，为多种信号分子提供了特定的微环境，使生化反应更高效、精准。在癌症发展进程中，LRs 参与调控多个关键环节，如细胞增殖、迁移和侵袭等，是极具潜力的抗癌药物靶点。

Most interesting, however, was the finding that this interaction required the β1 integrin subunit. The use of integrin subunit-blocking antibodies considerably blocked the adhesion of tumor cells ...

Taken together, these experiments demonstrate that RAB25 interacts directly with the β1 subunit of α5β1 to maintain a pool of actively cycling α5β1 integrin at the tips of extending pseudopodia.

More information: Ahmed Elwakiel et al, Factor XII signaling via uPAR-integrin β1 axis promotes tubular senescence in ...