Parkinson's symptoms mainly result from the death or impairment of dopamine-producing neurons in the brain's substantia nigra ...

Initial alpha-synuclein pathology may begin in the gut's own ... a disease in the same family as Parkinson's, which is characterized by early constipation and sleep disturbance, followed by ...

A new study contradicts previous research that suggests transurethral resection of the prostate (TURP) in patients with Parkinson disease ... in earlier studies. The pathology of lower urinary ...

Hearing impairment has emerged as a potential risk factor for Parkinson’s disease, a progressive neurodegenerative disorder that primarily manifests with motor impairments like tremors, rigidity, and ...

We demonstrate that recombinant alpha synuclein aggregates are toxic to primary cortical neuron cultures, are transferred between neurons, and induce Parkinson’s pSer129 pathology in mouse brains.

Parkinson’s disease (PD) is the second most common neurodegenerative disorder ... Inoculation with extracts from PD patients’ brains induces the development and spread of α-synuclein pathology in ...