A powerful technology called global protein stability profiling allows rates of protein turnover to be determined for a substantial fraction of the human proteome in a single experiment.

Scientists have uncovered a powerful ally in the fight against neurodegenerative diseases: a nucleolar complex that plays a pivotal role in maintaining cellular health through protein homeostasis ...

Proliferating animal cells maintain a stable size distribution over generations despite fluctuations in cell growth and division size. Previously, we showed that cell size control involves both cell ...

Courtesy of IBS The shaperon plays a role in maintaining protein homeostasis. It helps proteins fold correctly in three dimensions inside cells and prevents the aggregation of misfolded proteins, ...

Understanding bacterial growth mechanisms can potentially help uncover novel drug targets that are crucial for maintaining cellular viability, particularly for bacterial pathogens. In this important ...

elucidating the fundamental role of ribosomal proteins and ribosome homeostasis using protein-degradation and chemical proteomics tools. Multidisciplinary and quantitative approaches are central to ...

It is known that mitochondrial unfolded protein response (UPRmt), initiated by the transcription factor ATF5, maintains protein homeostasis under stress conditions by folding denatured proteins, ...

A recently published paper in Science China Life Sciences reports an interdisciplinary study utilizing single-cell sequencing ...