A powerful technology called global protein stability profiling allows rates of protein turnover to be determined for a substantial fraction of the human proteome in a single experiment.

The Cambridge, Massachusetts–based startup takes its name from the concept that to ensure health, every cell and tissue must preserve protein homeostasis, or 'proteostasis'. Because proteostasis ...

Protein homeostasis is the process by which cells manage protein synthesis, folding, and degradation. Disruptions in this balance result in the accumulation of misfolded proteins, which can lead ...

As we age, the intricate balance of protein homeostasis (proteostasis) -; the system responsible for maintaining cellular health by ensuring proteins are correctly folded-; begins to falter.

Scientists have uncovered a powerful ally in the fight against neurodegenerative diseases: a nucleolar complex that plays a pivotal role in maintaining cellular health through protein homeostasis ...

Protein homeostasis plays a central role in the proper functioning of cells. This process ensures that proteins are correctly produced, folded, degraded, and eliminated. A disruption of this ...

Protein homeostasis refers to regulating the functionality of every individual protein in the proteome. Proteins prone to misfolding present a particular challenge to cellular protein homeostasis and ...

Proliferating animal cells maintain a stable size distribution over generations despite fluctuations in cell growth and division size. Previously, we showed that cell size control involves both cell ...

elucidating the fundamental role of ribosomal proteins and ribosome homeostasis using protein-degradation and chemical proteomics tools. Multidisciplinary and quantitative approaches are central to ...

It is known that mitochondrial unfolded protein response (UPRmt), initiated by the transcription factor ATF5, maintains protein homeostasis under stress conditions by folding denatured proteins, ...

Understanding bacterial growth mechanisms can potentially help uncover novel drug targets that are crucial for maintaining cellular viability, particularly for bacterial pathogens. In this important ...