After treating a tumor with chemotherapy and radiotherapy, cells known as senescent cells can appear. These are cells that do ...

A new study describes a molecular mechanism that could drive the design of strategies to eliminate senescent cells in cancer ...

However, prolonged metabolic stress allows once-senescent liver cells to start dividing and progress to cancer. A MASH-inducing diet caused DNA damage in the liver cells (hepatocytes) of MUP-uPA mice.

Cellular senescence, where cells permanently stop dividing, plays a complex role in liver health. In a recent review article, ...

After treating a tumour with chemotherapy and radiotherapy, cells known as senescent cells can appear. These are cells that ...

2025 年的钟声刚刚敲响，四川大学已接连在 Nature、Science、Cell 三大国际顶刊上发表文章。 2025 年 1 月 1 日，四川大学古丽、重庆大学朱亚辉及加州大学圣地亚哥分校 Michael Karin 共同通讯在 Nature 在线发表题为 「FBP1 controls liver cancer evolution from senescent MASH hepatocytes ...

Accurately identifying and visualizing these cells in vivo is crucial for understanding their role in cancer biology and developing targeted therapies. Traditional methods for detecting senescent ...

The targeting of telomeres offers promise for new cancer therapies, which can be aimed at disrupting the mechanisms that ...

those caused by the accumulation of senescent cells (cells that stop dividing due to age or damage). Fasting and other dietary regimens are increasingly being explored as ways to starve cancer ...

They can fundamentally change how our cells function, right down to their DNA." More information: Li Gu et al, FBP1 controls liver cancer evolution from senescent MASH hepatocytes, Nature (2025).