However, as tumors evolve, they exploit the TIME to ... thereby influencing processes like immune escape, angiogenesis, and metastasis. HCC is particularly adept at manipulating the TIME via ...

Immunotherapy is based on harnessing a person's own immune system to attack cancer cells. However, patients with certain tumors do not respond to these therapies and it remains unclear why.

Immunotherapy, cancer treatments that alter the immune system, making it better apt to fight tumor cells, have provided novel ...

Many of the cells in the innate immune system produce cytokines or interact with other cells directly to activate the adaptive immune system. In cancer cells, mutations can lead to expression of tumor ...

The group has established a platform to combine the study of human tissue specimens and mouse models of cancer to address key questions ranging from mechanisms of immune escape and treatment failures ...

Much of our knowledge of the protein PD-1, a leading cancer ... to escape the effects of rodent-specific pathogens. "The rodent ancestors survived the extinction event but their immune receptor ...

Yet treatments leveraging PD-1 are only effective in a small fraction of cancer ... escape the effects of rodent-specific pathogens. "The rodent ancestors survived the extinction event but their ...

Endosomal escape and removal through macrophages of lipid nanoparticles is possible without ... benefit in multiple cancer indications as well as the activation of a targeted and sustained, ...