Whereas small-molecule inhibition and the moderate overexpression of catalytic mutants simply reduces Aurora B kinase activity in the cell, RNAi disrupts the CPC, leading to a more global ...

1Department of Thoracic/Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. 2The University of Texas MD Anderson Cancer Center, UTHealth Houston Graduate ...

Eligible patients are those with hemophilia A or B, who are 12 and older, and have inhibitors, a type of neutralizing antibody against blood clotting proteins that can render standard preventive ...

Rasagiline demonstrates complete and selective inhibition of MAO-B and is at least five times more potent than selegiline. Unlike selegiline, which is metabolized to amphetamine derivatives ...

Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China University of Chinese Academy of Sciences, No. 19A ...

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Calcitonin gene-related peptide (CGRP) inhibitors are now considered a first-line treatment used to treat and prevent migraines. There are two types of CGRP medications: monoclonal antibodies and ...

This study presents a valuable finding on the role of secretory leukocyte protease inhibitors (SLPI) in developing Lyme disease in mice infected with Borrelia burgdorferi. The evidence supporting the ...

Copyright held by the owner/author(s). This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International ...

Dara Khosrowshahi is resigning from the board of autonomous vehicle technology company Aurora Innovation, citing a desire to focus on his ongoing responsibilities as CEO of Uber and reduce ...

Molson Coors Beverage Co. Cl A 7.89% $11.14B Molson Coors Beverage Co. Cl B 2.07% $11.14B ...