Mammalian genomes are organized by multi-level folding, yet how this organization contributes to cell type-specific transcription remain unclear. We uncovered that the nuclear protein SATB1 ...

The improper segregation of chromosomes during cell division leads to abnormalities that disrupt the proper functioning of ...

Scientists discovered a way to block hepatitis B infection using an anticancer drug, offering hope for new treatments.

They are formed in a woman's body before birth and have to be on standby for decades to possibly be fertilized one day. But ...

Researchers at the Arc Institute, Stanford University, and NVIDIA have developed Evo 2, an advanced AI model capable of ...

Strikingly, a Mb long inactive artificial bacterial chromosome was able to bind plasmid molecules from their native binding positions, illustrating how the plasmid is spontaneously attracted by ...

It revealed that the HBV X gene, which produces HBx protein, is particularly sensitive to the formation of nucleosomes-the basic units of chromatin, made of histone proteins, which package and ...

Nucleosomes are like beads on a string—the string is the viral DNA, and the beads are host-provided histone proteins, around which DNA gets wrapped; nucleosomes are the building blocks of chromatin, ...

Together, these bead-like structures form chromatin fibres that fold up tightly into chromosomes. Folded chromatin structures are not random, however. They are determined by the genetic code and, in ...

1Department of Nephrology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China. 4Department of Urology, Shanghai ...