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扩散模型+深度学习双剑合璧,生成式AI破解染色质构象
图 1:ChromoGen 在使用序列数据对染色质组织进行从头预测时遵循的程序图示。(图源:论文) 微调的 EPCOT 模型将 DNA 序列和脱氧核糖核酸酶序列(DNase-seq)数据转换为信息丰富的低维数字嵌入。接下来,由微调模型创建的嵌入使用无分类器指导的去噪扩散概率 ...
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