Shanghai Henlius Biologics Co. Ltd. has synthesized histone acetyltransferase KAT6A (monocytic leukemia zinc finger protein; MOZ; MYST-3) and/or histone acetyltransferase KAT6B (MOZ2; MYST-4) ...

Post-translational modifications of DNA and histones are epigenetic mechanisms, which affect the chromatin structure, ultimately leading to gene expression changes. A number of different epigenetic ...

Epigenetic and related enzymes regulate gene expression by modifying DNA, RNA, or histones, influencing chromatin structure and RNA function. SignalChem Biotech offers a range of these enzymes, ...

Histone acetylation has been shown to play a crucial role in memory formation, and histone deacetylase (HDAC) inhibitor sodium butyrate (NaB) has been demonstrated to improve memory performance and ...

These useful findings assigned a novel functional implication of histone acylation, crotonylation. Although the mechanistic insights have been provided in great detail regarding the role of the YEATS2 ...

实验表明，该位点的竞争拮抗作用会减弱 KAT7 的组蛋白乙酰转移酶（Histone Acetyltransferase，HAT）活性，影响其对底物 H3K14 和 H4K5/8/12 的乙酰化水平。 hMOF 是 DNA 损伤刺激下 KAT7 的主要巴豆酰基转移酶：研究人员通过一系列实验，包括转染不同的组蛋白巴豆酰基转移 ...

This month's cover highlights the article Nup358 restricts ER-mitochondria connectivity by modulating mTORC2/Akt/GSK3β signalling by Joseph, Misha Kalarikkal and colleagues. The image shows a human ...

Enzyme mechanisms are the chemical transformations, and the steps within them, generated by enzymatic action on substrates. The mechanism of enzyme catalysis is similar in principle to other types ...

Cancer cells are known to favor aerobic glycolysis for energy production, a phenomenon termed the Warburg effect.

In this valuable study, the authors studied a novel Zn2+- and NAD+-independent KDAC protein, AhCobQ, in Aeromonas hydrophila, which lacks homology with eukaryotic counterparts, thus underscoring its ...