A new review highlights the pivotal role of LSD1 (lysine-specific demethylase 1) in regulating critical cellular processes ...

Histone methylation plays a primary role in regulating gene transcription. Histone lysine methylation is catalyzed by lysine methyltransferases (KMTs) in the presence of SAM as the methyl donor. The ...

Here, we show that Set1, the catalytic subunit of the highly conserved Set1C/COMPASS complex responsible for histone H3K4 methylation (H3K4me), behaves as a repressor of the transcriptome largely ...

This is important since recombination in heterochromatin can create genetic abnormalities. Adding small chemical modifications—such as methyl groups—to the histone proteins at the core of the ...