Deregulation of these processes is a hallmark of cancer. For instance, G9a, a histone methyltransferase responsible for histone H3 lysine 9 (H3K9) mono- and dimethylation, has been observed to be ...

State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong 999077, China Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of ...

The treatment of hepatocellular carcinoma (HCC) has made progress due to immune checkpoint inhibitors (ICIs), but still many patients present innate or acquired resistance to ICIs, thus there is a ...

Mutations of the histone H3K36-specific methyltransferase ASH1L have been linked to several human diseases. Here, the authors report the mechanism by which three C-terminal domains in ASH1L ...

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Patient 1 is a 5-year-and 9-month-old female, who initially presented to the outpatient clinic of the Catholic University of Korea, Eunpyeong St. Mary’s Hospital at 4 years and 10 months, due to ...

Insect miRNAs can be transferred to their host plants upon feeding. This study shows that a conserved insect microRNA plays a ...

The new gene therapy aims to address the root cause of prion disease by using the CHARM epigenetic editing platform from the Whitehead Institute to target and silence the gene that codes for the ...

During myogenic differentiation the cellular architecture and proteome of muscle stem cells and myoblasts undergo extensive remodeling. These molecular processes are only partially understood and ...

该朊病毒基因治疗通过CHARM（Coupled Histone tail for Autoinhibition Release of Methyltransferase）来靶向和沉默编码致病蛋白的基因，由Apertura公司的AAV ...