The new gene therapy aims to address the root cause of prion disease by using the CHARM epigenetic editing platform from the Whitehead Institute to target and silence the gene that codes for the ...

State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong 999077, China Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of ...

Methylation of PP2Ac is primarily mediated by leucine carboxyl methyltransferase-1 (LCMT-1). Demethylation is controlled by an esterase, PP2A methylesterase (PME-1). We tested two potential LCMT-1 ...

This is generally a well-designed and carefully conducted study that is likely to be of interest to many both inside and outside of the field of lung tumorigenesis and normal lung development and ...

Regeneration is the process by which lost or damaged tissues, organs or limbs are re-formed from the remaining tissue. During regeneration, adult stem cells and/or progenitor cells differentiate ...

Molecular mechanisms that exert epigenetic control of gene expression contribute to age-associated neuronal impairments. Both DNA methylation, mediated by DNA methyltransferases (DNMTs), and histone ...

In this paper, we identify MLL4 as a major H3K4 mono- and di-methyltransferase enriched on mammalian enhancers. We show MLL4 is essential for enhancer activation, cell-type-specific gene expression, ...