Across the solid-tumor spectrum, many patients are burdened with metastatic, immune-excluded or immune-desert tumors that do not respond to checkpoint monoclonal antibodies. Systemically ...

A new review article published in Genes & Diseases sheds light on the complex molecular mechanisms through which ...

A new review article published in Genes & Diseases sheds light on the complex molecular mechanisms through which tumor-infiltrating immune cells regulate endometrial carcinoma (EC). As one of the most ...

In addition, immune T cells, typically in charge of fighting the tumor, were excluded from the tumor microenvironment, reducing the ability of the immune system to eliminate the tumor. Importantly ...

Through a mouse study, scientists have found that aspirin may help prevent metastases, or secondary tumors, by boosting the ...

ImmunoGenesis doses 1st patient in phase 1/2 trial of IMGS-101 in combo with balstilimab & zalifrelimab to treat immune-excluded tumours: Houston Saturday, March 8, 2025, 18:00 Hr ...

Solid tumors often provide a challenging environment for the T cells of our immune system. By reprogramming the metabolism of ...

Researchers at the University of Texas MD Anderson Cancer Center have developed a novel antibody-toxin conjugate (ATC) ...

For decades, scientists have explored the potential of bacteria in fighting cancer, but safety and efficacy barriers have ...

Pancreatic cancer remains one of the most challenging tumors to treat, partly because it is often discovered at advanced stages when the disease has already spread, or metastasized. About half of ...

When blood cancer cells break through the bone and multiply, tumor cells become dangerously diverse and the immune response in the region changes, report researchers from Berlin and Heidelberg in ...

Dr. Vinod Balachandran says mRNA vaccines could stimulate the immune system to recognize and attack pancreatic cancer cells. An experimental approach to treating pancreatic cancer with the messenger ...