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生物通
1y
RNA修饰隐藏的神秘调控
m6A是真核生物mRNA上含量最丰富的化学修饰,由甲基转移酶复合物(包含METTL3,METTL14,WTAP,KIAA1429,RBM15,RBM15B)催化产生,可被去甲基化酶ALKBH5或FTO去除。 m1A m1A是新近发现的可逆的表观转录 ...
14d
三篇顶刊,新型RNA修饰----糖基化GlycoRNA
2021 年,一篇题为“Small RNAs are modified with N - glycans and displayed on the surface of living cells”的论文在 Cell ...
生物通
1y
Arraystar 表观转录组芯片
RNA转录后修饰,比如m6A, m1A, m5C, 和假尿嘧啶(Ψ)修饰,共同组成了表观转录组,是一种新层次的基因表达调控方式。m6A是mRNA和lncRNA上含量最丰富的修饰,在转录后各个水平影响mRNA/lncRNA 的代谢 ...
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