In addition, macrophage polarization is regulated by two opposing pathways in arginine metabolism: The iNOS pathway, which produces citrulline and NO from arginine, induces the generation of M1 ...

smu.edu.cn, baixc15{at}smu.edu.cn Objectives To investigate the roles and regulatory mechanisms of synovial macrophages and their polarisation in the development of osteoarthritis (OA). Methods ...

Mechanistic studies showed that Lrrk2 promotes macrophage polarization toward the M1 phenotype by enhancing STAT1 phosphorylation in response to IFN-γ signaling. This function is dependent on the ...

Department of Pharmaceutics, School of Pharmacy, Nantong University, Nantong 226001, China ...

Inhibition of PI3Kγ facilitates macrophage antigen presentation and prevents M2 polarisation resulting in a robust CD8+ T cell mediated antitumour response. Immunotherapies are providing impressive ...

but successfully running it on the M1, M2, etc, is still not always possible. You have to test which OS runs and on a specific set of settings to get it right. Anything and everything because titles ...

The underlying regulatory mechanisms of metabolic switching are assessed by both in vitro and in vivo studies. Conclusions Selectively modulating the ‘context’ of glycolytic macrophages in HCC tumours ...