2 Department of Hepatobiliary Surgery, St James's University Hospital, Leeds Teaching Hospitals NHS Trust, Leeds, UK Correspondence to Professor Mark Hull, Leeds Institute of Molecular Medicine, ...

Introduction: The impact of spaceflight on the immune system and mitochondria has been investigated for decades. However, the molecular mechanisms underlying spaceflight-induced immune dysregulations ...

The endothelium, which forms the inner lining of all blood vessels, is a highly selective barrier for blood constituents. Formation of gaps between endothelial cells (ECs), for instance during ...

The high interstitial ATP concentration in the cancer microenvironment is a major source of adenosine, which acts as a strong immune suppressor. However, the source of ATP release has not been ...

He then became an HFSP Postdoctoral Fellow at the University of California, Berkeley. At Berkeley, he studied actin cytoskeleton assembly and sphingolipid biosynthesis in budding yeast. Since 2015 he ...

Sphingolipid and deoxysphingolipid measurements were performed by liquid chromatography–tandem mass spectrometry (LC–MS/MS) analysis as described in previous studies. (12,13,28−30) First, cell pellets ...

S1Rs are single 223 amino acid polypeptides (26 kDa) with a trimeric architecture of the protomers in the crystal structure that was revealed to include two transmembrane domains per protomer (13) ...