3,4 (3) CAR T cells that perform combinatorial logic operations help cells discriminate between healthy and cancerous cells and hone their attack, thus reducing toxicity. For example, activation of a ...

But that doesn’t work if the CARs are being blocked, so Lim and colleagues gave the cells an alternate activating receptor called synNotch, which they predicted would be able to bypass a tumor’s ...

They found that the SNAP-SynNotch receptors could be activated in response to various targets in vitro when the relevant antibodies were added. Next, the researchers hope to test the SNAP-CAR-T cell ...