3.2 Axis of Atg2-AMPK/Sirt1/PGC-1α (human ATG2-AMPK/SIRT1/PGC-1α) pathway postpones age-related deteriorations of skeletal and cardiac muscle in Drosophila Autophagy associated TOR and FOXO associated ...

Discover how practical strategies can activate autophagy, your body's cellular cleanup mechanism linked to longevity and ...

Here, we found that inhibition of AMPK occurs during naïve transition with two conventional inhibitors of the MEK1 and GSK3β pathways. The accumulation of glycogen due to iGSK3β is responsible for ...

Autophagy is a cellular degradation pathway for the clearance of damaged or superfluous proteins and organelles. The recycling of these intracellular constituents also serves as an alternative ...

Intracellular ferrous ion concentration was detected by FerroOrange fluorescent probe staining. Western blotting and immunofluorescence staining were used to detect biomarker proteins of ferroptosis, ...

enhancing autophagy, resulting in chemotherapeutic resistance, epithelial-mesenchymal transition (EMT), and invasion. Activation of the LKB1-AMPK-mTOR pathway protects tumor cells from anoikis ...

Moreover, this review summarizes the anti-cancer molecular mechanisms of ICA, such as apoptosis, necrosis, autophagy, senescence, metastasis, angiogenesis, and immunomodulation. The primary aim of ...

Longevity research has propelled the scientific community to concentrate on interventions that do more than simply add years ...