Discover how practical strategies can activate autophagy, your body's cellular cleanup mechanism linked to longevity and ...

Autophagy is a process by which cellular material is degraded by lysosomes or vacuoles and recycled. Several autophagy pathways operate within a cell, including macroautophagy, microautophagy and ...

enhancing autophagy, resulting in chemotherapeutic resistance, epithelial-mesenchymal transition (EMT), and invasion. Activation of the LKB1-AMPK-mTOR pathway protects tumor cells from anoikis ...

Here, we found that inhibition of AMPK occurs during naïve transition with two conventional inhibitors of the MEK1 and GSK3β pathways. The accumulation of glycogen due to iGSK3β is responsible for ...

Moreover, this review summarizes the anti-cancer molecular mechanisms of ICA, such as apoptosis, necrosis, autophagy, senescence, metastasis, angiogenesis, and immunomodulation. The primary aim of ...

Department of Pharmacy and Institute of Inflammation, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital (X.H., Y.Z., Y.W., G.L.) Zhejiang ...

More information: Isabel Gordaliza-Alaguero et al, Endogenous interactomes of MFN1 and MFN2 provide novel insights into interorganelle communication and autophagy, Autophagy (2024). DOI: 10.1080 ...

Endogenous interactomes of MFN1 and MFN2 provide novel insights into interorganelle communication and autophagy. Autophagy , 2024; 1 DOI: 10.1080/15548627.2024.2440843 Cite This Page : ...

Compared with young macrophages, old macrophages accumulated more lipid droplets upon lipid loading with the pro-atherogenic lipoprotein aggregated LDL (low-density lipoprotein), accompanied by a ...

Subsequently, the upstream signal of autophagy was analyzed and it was found that Ad-VT reduced the resistance of cells to doxorubicin by reducing the level of mTOR, and then the analysis of the ...