Discover how practical strategies can activate autophagy, your body's cellular cleanup mechanism linked to longevity and ...

enhancing autophagy, resulting in chemotherapeutic resistance, epithelial-mesenchymal transition (EMT), and invasion. Activation of the LKB1-AMPK-mTOR pathway protects tumor cells from anoikis ...

Methods: In this study, we used a rat model of PCOS induced by letrozole and a high-fat diet. The effect of intestinal AMP-activated protein kinase (AMPK) activation was evaluated through metformin ...

Here, we found that inhibition of AMPK occurs during naïve transition with two conventional inhibitors of the MEK1 and GSK3β pathways. The accumulation of glycogen due to iGSK3β is responsible for ...

Moreover, this review summarizes the anti-cancer molecular mechanisms of ICA, such as apoptosis, necrosis, autophagy, senescence, metastasis, angiogenesis, and immunomodulation. The primary aim of ...

Department of Pharmacy and Institute of Inflammation, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital (X.H., Y.Z., Y.W., G.L.) Zhejiang ...