Whereas small-molecule inhibition and the moderate overexpression of catalytic mutants simply reduces Aurora B kinase activity in the cell, RNAi disrupts the CPC, leading to a more global ...

Rasagiline demonstrates complete and selective inhibition of MAO-B and is at least five times more potent than selegiline. Unlike selegiline, which is metabolized to amphetamine derivatives ...

Aurora aims to deliver the benefits of self-driving technology safely, quickly, and broadly to make transportation safer, increasingly accessible, and more reliable and efficient than ever before ...

Sitala Bio Ltd. has prepared new indole derivatives acting as complement factor B (CFB) inhibitors. They are thus reported to be useful for the treatment of age-related macular degeneration, ...

By mid-2024 the Food and Drug Administration had approved 81 small-molecule kinase inhibitors targeting greater than 30 kinases, providing substantial clinical benefits for patients with cancer and ...

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The factor B inhibitor also allowed significantly more patients to meet the haemoglobin target of 12g/dl than the antibody therapies, fulfilling both primary objectives of the trial.

Molson Coors Beverage Co. Cl A-7.50% $11.29B Molson Coors Beverage Co. Cl B-2.48% $11.29B ...