Mammalian genomes are organized by multi-level folding, yet how this organization contributes to cell type-specific transcription remain unclear. We uncovered that the nuclear protein SATB1 ...

The improper segregation of chromosomes during cell division leads to abnormalities that disrupt the proper functioning of ...

“We wanted to have a technique to look at the structure of an entire chromosome at kilobase resolution,” recalls Dekker. Unlike previous chromatin conformation capture methods that interrogate ...

During mitosis, the chromatin undergoes a dynamic reorganization important for faithful chromosome segregation. Here the authors show that the DEAD-box RNA helicase eIF4A1/2 regulates the ...

Scientists discovered a way to block hepatitis B infection using an anticancer drug, offering hope for new treatments.

In a groundbreaking study that could be described as a ‘crucial step’ towards unraveling the secrets of longevity, scientists have linked the longer lifespans of women to chromosomes. Let’s delve ...

The applied physicist explains how the structure of 52,000-year-old genes hint at the biology of an extinct animal ...

The second act of a popular reprogramming factor could maximize the potential of iPSCs in research and regenerative medicine.