Therefore, chromatin is further coiled into an even ... the DNA becomes highly compacted into the classic metaphase chromosomes that can be seen with a light microscope. Once a cell has divided ...

Mammalian genomes are organized by multi-level folding, yet how this organization contributes to cell type-specific transcription remain unclear. We uncovered that the nuclear protein SATB1 ...

Together, these bead-like structures form chromatin fibres that fold up tightly into chromosomes. Folded chromatin structures are not random, however. They are determined by the genetic code and, in ...

The improper segregation of chromosomes during cell division leads to abnormalities that disrupt the proper functioning of ...

Strikingly, a Mb long inactive artificial bacterial chromosome was able to bind plasmid molecules from their native binding positions, illustrating how the plasmid is spontaneously attracted by ...

The results demonstrated that p53 mediates chromatin interactions between Ad-p53 and various regions of the host chromosome (Figure 3A), with particularly high interaction frequencies observed on ...

Chromosomes and Gene Expression eLife reviews research ranging from transcription and RNA processing to epigenetics and chromatin biology. Learn more about what we review and sign up for the latest ...

each chromosome occupies its own specific region in the nucleus. "If we look at the average chromatin structures in human cells and many other organisms, we will see that chromosomes seem to be ...

Scientists discovered a way to block hepatitis B infection using an anticancer drug, offering hope for new treatments.

They are formed in a woman's body before birth and have to be on standby for decades to possibly be fertilized one day. But ...