Mammalian genomes are organized by multi-level folding, yet how this organization contributes to cell type-specific transcription remain unclear. We uncovered that the nuclear protein SATB1 ...

The improper segregation of chromosomes during cell division leads to abnormalities that disrupt the proper functioning of ...

Scientists discovered a way to block hepatitis B infection using an anticancer drug, offering hope for new treatments.

They are formed in a woman's body before birth and have to be on standby for decades to possibly be fertilized one day. But ...

Strikingly, a Mb long inactive artificial bacterial chromosome was able to bind plasmid molecules from their native binding positions, illustrating how the plasmid is spontaneously attracted by ...

The results demonstrated that p53 mediates chromatin interactions between Ad-p53 and various regions of the host chromosome (Figure 3A), with particularly high interaction frequencies observed on ...

Yeast also has the same way of organizing chromosomes, while in humans and other mammals, each chromosome occupies its own specific region in the nucleus. “If we look at the average chromatin ...

It revealed that the HBV X gene, which produces HBx protein, is particularly sensitive to the formation of nucleosomes-the basic units of chromatin, made of histone proteins, which package and ...

each chromosome occupies its own specific region in the nucleus. "If we look at the average chromatin structures in human cells and many other organisms, we will see that chromosomes seem to be ...

Nucleosomes are like beads on a string—the string is the viral DNA, and the beads are host-provided histone proteins, around which DNA gets wrapped; nucleosomes are the building blocks of chromatin, ...

Genes are encoded in the DNA that makes up chromosomes, which consist of DNA wrapped around proteins, forming a complex structure called chromatin. To be functional, the genes must be expressed.