A new review highlights the pivotal role of LSD1 (lysine-specific demethylase 1) in regulating critical cellular processes ...

Cancer cells are known to favor aerobic glycolysis for energy production, a phenomenon termed the Warburg effect.

PDHX acetylation promotes tumor progression by disrupting PDC assembly and activating lactylation-mediated gene expression.

Histamine, like serotonin and dopamine, is involved in histone monoaminylation. The Maze group recently described H3 histaminylation which is also catalyzed by TGM2 and occurs at the same position on ...

“HDACi increases histone acetylation, which in turn modulates the expression of genes that counteract proliferation of pulmonary arterial smooth muscle and endothelial cells, endothelial ...

These useful findings assigned a novel functional implication of histone acylation, crotonylation. Although the mechanistic insights have been provided in great detail regarding the role of the YEATS2 ...

Histone acetylation is usually associated with transcriptional activation because the affinity of histone proteins for DNA is reduced and chromatin packaging is relaxed. Histone methylation ...

These findings indicate that RBM14 is an essential modulator of oocyte meiotic maturation by regulating α-tubulin acetylation to affect spindle morphology and chromosome alignment. Consequently, RBM14 ...

Acetylation is any chemical reaction that adds an acetyl chemical group (CH3C=O, sometimes abbreviated in chemical structures as Ac) and is a type of acylation reaction. Acetylation of proteins ...

Acetylation of these amines with acetyl transferases converts amines to N-acetyl amines (acetamides) and stops the formation of the positive charges. On the other hand, deacetylation of acetamides ...

Mechanistically, 8C reduced I/R injury by promoting histone acetylation which in turn activated the expression of antioxidant genes and inhibited cardiomyocyte (CM) apoptosis. Furthermore, we ...