A new review highlights the pivotal role of LSD1 (lysine-specific demethylase 1) in regulating critical cellular processes ...

The dimethylation of IRF3 at lysine 39 was increased upon viral infection, and the methylation of IRF3 at lysine 39 resulted in the loss of its activity. To validate their findings, researchers used ...

Researchers led by the University of Ulsan College of Medicine, Korea, have checked the performance of a noninvasive urinary DNA methylation test for bladder cancer diagnosis. Findings indicate ...

Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110, United States ...

2025年2月11日，国际顶级植物学期刊Nature Plants在线发表了题为 “Histone H3 lysine 4 methylation recruits DNA demethylases to enforce gene ...

State Key Laboratory of Crop Genetics and Germplasm Enhancement, Jiangsu Provincial Key Laboratory for Organic Solid Waste Utilization, College of Resources and Environmental Sciences, Nanjing ...

Histone lysine demethylases; LSD, Lysine-specific demethylases; MBDs, Methyl-CpG binding domains; MyD88, Myeloid differentiation factor 88; MLL, Mixed-lineage leukaemia; NF-κB, Nuclear factor kappa B; ...

Histone methylation results in various transcriptional consequences depending on histone number and the lysine residue modified. For example, histone H3 methylation at lysine 9 is associated with ...

Histone methylation plays a primary role in regulating gene transcription. Histone lysine methylation is catalyzed by lysine methyltransferases (KMTs) in the presence of SAM as the methyl donor. The ...

Here, we show that Set1, the catalytic subunit of the highly conserved Set1C/COMPASS complex responsible for histone H3K4 methylation (H3K4me), behaves as a repressor of the transcriptome largely ...