Deregulation of these processes is a hallmark of cancer. For instance, G9a, a histone methyltransferase responsible for histone H3 lysine 9 (H3K9) mono- and dimethylation, has been observed to be ...

State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong 999077, China Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of ...

Beyond established roles in collagen biosynthesis, hypoxic signaling and fatty acid metabolism, recent reports have now revealed roles for human 2-oxoglutarate–dependent oxygenases in histone ...

Major depressive disorder (MDD) is a psychiatric disorder with increasing prevalence worldwide. It is a leading cause of disability and suicide, severely affecting physical and mental health. However, ...

Mammalian genomes are organized by multi-level folding, yet how this organization contributes to cell type-specific transcription remain unclear. We uncovered that the nuclear protein SATB1 ...

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Insect miRNAs can be transferred to their host plants upon feeding. This study shows that a conserved insect microRNA plays a ...

This important paper reports functional interactions between L1TD1, an RNA binding protein (RBP), and its ancestral LINE-1 retrotransposon which is not modulated at the translational level. The ...

The new gene therapy aims to address the root cause of prion disease by using the CHARM epigenetic editing platform from the Whitehead Institute to target and silence the gene that codes for the ...

该朊病毒基因治疗通过CHARM（Coupled Histone tail for Autoinhibition Release of Methyltransferase）来靶向和沉默编码致病蛋白的基因，由Apertura公司的AAV ...