Researchers at Fred Hutch Cancer Center have discovered an overlooked mechanism driving aggressive breast and brain tumors ...

The lab of Filippo Veglia, Ph.D., at The Wistar Institute has discovered a previously unknown mechanism for how aggressive ...

Scientists have discovered a previously unknown mechanism for how aggressive brain cancers reprogram immune system cells from fighting cancer to enabling further tumor growth.

In histone lactylation, incompletely metabolized lactate produces by-products that attach molecules called lactyl groups to histones, and those modified histones cause changes in gene expression.

Monoamines, basic nitrogenous molecules containing one amine group ... Histamine, like serotonin and dopamine, is involved in histone monoaminylation. The Maze group recently described H3 ...

Molecular glue degraders are small molecules that promote the interaction ... repressor complex ‘LHC’, comprised of the histone demethylase LSD1, the histone deacetylase HDAC1 (or HDAC2 ...

In response to specific stimuli, eosinophils also undergo a type of lytic cell death, referred to as eosinophil extracellular trap (EET)-associated cell death (EETosis), where histone citrullination ...

Their data reveal that UM171 acts as a molecular glue between KBTBD4 and a subunit of the CoREST complex called histone deacetylase 1 (HDAC1), an enzyme that chemically modifies DNA-packaging ...