The most dramatic phenotypes tend to be lost, as gross perturbations of immunity are likely to kill mice in a colony before the causal mutations achieve fixation by chance. Genetic differences are ...

A second limitation to ENU mutagenesis is that G1 mice are expected to carry quite a few recessive lethal mutations, which make the litter size of G3 colonies much smaller than expected and ...

Researchers at Karolinska Institutet have uncovered new insights into the mechanisms underlying autism spectrum disorder (ASD ...

The mouse model closely mimics the specific dysferlin mutation and resulting disease, and enabled the researchers to evaluate how the complete therapy works—taking muscle stem cells, correcting ...

Researchers at Texas Biomed have identified nine mutations in a strain of bird flu found in a person in Texas. Bad news: This ...

Mutations in one of the first human-isolated strains of H5N1 bird flu in the US were identified by the Texas Biomedical ...

Researchers at the Broad Institute of MIT and Harvard have developed a gene-editing treatment for prion disease that extends lifespan by about 50 percent in a mouse model of the fatal ...

It’s essentially been unknown.” Introducing individual mutations to mtDNA is challenging due to the large number of mitochondria within each cell. Instead, the researchers used a leukemia mouse model ...