Researchers have identified genetic variations in brain cells, particularly microglia and oligodendrocytes, that influence both aging and Alzheimer’s risk.
They also used RNA sequencing data – a technique used to help understand which genes are active and how much they change with ageing and disease – from both mice and people to study gene activity (how ...
The research revealed that dark microglia produce and release toxic lipids that damage neurons and oligodendrocyte progenitor cells, which are essential for brain function and are most impacted in ...
Researchers at the CUNY Graduate Center have identified the integrated stress response in microglia as a key factor linking stress in the brain to Alzheimer's disease progression. Their study ...
These lipids damage neurons and oligodendrocyte progenitor cells — two cell types that are essential for brain function and are most impacted in Alzheimer’s disease. But scientists found that ...
This knowledge gap motivates the development of effective models to study the role of environmental cues in oligodendrocyte progenitor cell (OPC ... The brightness of each channel was adjusted using ...
Table 1. Mutations identified in KCNJ10/Kir4.1. We will start by describing the typical symptoms seen in most patients carrying loss-of-function mutations in Kir4.1, affecting both homomeric as well ...