为解决败血症相关肺纤维化（PF）治疗难题，上海交通大学医学院附属仁济医院研究人员探究 PKM2 对 AECs 线粒体动力学和 EMT 的调控。结果发现 PKM2 是关键调节因子，抑制它可缓解 PF。推荐一读，或为相关研究带来新思路。 在医学领域，急性呼吸窘迫综合征（ARDS ...

This important study reveals that disrupting fatty acid metabolism in macrophages significantly restricts the growth of Mycobacterium tuberculosis, showing that impaired lipid processing triggers ...

Macrophages in the tumor microenvironment (TME) promote tumor cell metastasis through various mechanisms, including angiogenesis and immunosuppression, and play a unique role in the development of ...

One type of immune cell residing in nerves, a pro-inflammatory macrophage, began producing chemokines. These signaling molecules recruited a second population of circulating macrophages ...

A pivotal role of P21-activated kinase 5 (PAK5) in endometriosis progression has been uncovered, revealing that PAK5-mediated phosphorylation of pyruvate kinase M2 (PKM2) is critical for anaerobic ...

Integrating changes in signal transduction pathways and cellular metabolism is essential for effective NK cells responses. The glycolytic enzyme Pyruvate Kinase Muscle 2 (PKM2) has described roles in ...

Metabolic reprogramming during macrophage polarization supports the effector functions of these cells in health and disease. Here, we demonstrate that pyruvate dehydrogenase kinase (PDK), which ...