Prolonged illnesses like cancer and chronic infections often leave the immune system in a state of exhaustion, where its ...

Prolonged illnesses like cancer and chronic infections often leave the immune system in a state of exhaustion, where its ...

Researchers have developed a groundbreaking AI model that identifies tumor-fighting immune cells, enhancing cancer ...

3.1 UPR molecules and T cell activation When T cells contact with an APC, the T cell receptor (TCR) activation induces a series of intracellular pathways that result in the activation of the UPR. This ...

Scientists have uncovered a mechanism for reinvigorating the immune system to stop it from flagging when it’s fighting ...

In patients with RCC, exceptional response to immunotherapy may be related to clonal neoantigen-driven cytotoxic T-cell ...

The three-signal paradigm tries to capture how the innate immune system instructs adaptive immune responses in three well-defined actions: (1) presentation of antigenic peptides in the context of MHC ...

Prolonged illnesses like cancer and chronic infections often leave the immune system in a state of exhaustion, where its frontline defenders – T cells – lose their ability to function effectively.

Preliminary findings from the phase 1 trial showed that GCC19CART, a novel CAR T-cell therapy, demonstrated clinical ...

MB-105, a first-in-class CD5-targeted CAR T-cell therapy, received FDA orphan drug designation for relapsed/refractory T-cell ...