Here we review the current knowledge on specific, low-abundant histone ubiquitination events that are highly regulated within the cellular DNA damage response (DDR), with particular emphasis on the latest discovery of Ub phosphorylation as a novel regulator of the DDR signaling pathway.

Histone ubiquitination is a reversible modification whose steady state is determined by two enzymatic activities involved in addition and removal of the ubiquitin moiety from histones.

2024年9月1日 · Ubiquitination of histone plays a key role in transcription, replication, and DNA damage response. Histone ubiquitination regulates other PTMs to preserve genome integrity. Maintenance of genome integrity is a precise but tedious and complex job for the cell.

2023年3月3日 · Histone H2A monoubiquitination (H2Aub1) functions as a conserved posttranslational modification in eukaryotes to maintain gene expression and guarantee cellular identity. Arabidopsis H2Aub1 is...

One PTM on histones, mono-ubiquitylation, has emerged as a key player in cellular response to DNA damage. In this review, we will (1) briefly summarize the history of histone H2A and H2B ubiquitylation (H2Aub and H2Bub, respectively), (2) discuss their roles in transcription, and (3) their functions in DDR.

2020年6月1日 · Histone ubiquitination is at the heart of the DDR, functioning as a signaling platform that integrates multiple inputs from inside and outside the cell. While the impact of histone H3 and H4 ubiquitination in the DDR is far from clear, the effect of DNA damage-induced ubiquitination of histones H2A, H2B, and H1 has been addressed in recent studies.

2021年1月20日 · Here we review the current knowledge on specific, low-abundant histone ubiquitination events that are highly regulated within the cellular DNA damage response (DDR), with particular emphasis on...

Several histone lysine residues in the mammalian genome have been identified as substrates for histone ubiquitination, and their modifications play a role in various processes including chromatin regulation, DNA repair, and transcription [40,41,42].

2008年3月28日 · In this review, we present the enzymes involved in H2A and H2B ubiquitination and discuss new evidence that links histone ubiquitination to other chromatin modifications, which has provided a model for the role of H2B ubiquitination, in particular, in …

2012年3月12日 · In particular, we will focus on how they are regulated by histone ubiquitin ligases and deubiquitinating enzymes. We will then discuss the roles of histone ubiquitination in transcription and DNA damage response and the crosstalk between histone ubiquitination and other histone modifications.